The web world is moving fast:
Older browsers like IE6/7 are being left behind (even IE8 in jQuery 2.0), enabling a lot of new possibilities for front end development.
Mobile first web design is starting to make his way into the major front-end frameworks: Zurb has already released Foundation 4 and Twitter will soon release Bootstrap 3 (preview here).
The're both using CSS preprocessors (SASS / LESS), harmonizing differences between browsers with normalize.css, detecting features with Modernizr...
2013 is going to be exciting, playing with all of this new toys!